The Chemistry of Organolithium Compounds - download pdf or read online

By B. J. Wakefield (Auth.)

ISBN-10: 0080176402

ISBN-13: 9780080176406

Show description

Read or Download The Chemistry of Organolithium Compounds PDF

Similar organic books

The Chemistry of Heterocyclic Compounds, Oxazoles: - download pdf or read online

Synthesis, Reactions, and Spectroscopy offers a accomplished assessment of the literature from 1983 to the current overlaying oxazoles, mesoionic oxazoles, oxazolones, oxazolines, and chiral bisoxazolines. In-depth assurance contains synthesis, reactions, spectroscopic and actual houses for every classification of compounds, in addition to vital advancements concerning using these compounds.

Symmetry Properties of Molecules - download pdf or read online

The purpose of the current article is to offer a serious exposition of the idea of the symmetry homes of inflexible and nonrigid molecules. even though a number of bills of the topic, either technical and didactic, at the moment are to be had, and regardless of the huge dialogue of nonrigid molecule symmetry that has been happening because the vintage papers of Hougen and Longuet-Higgins, there continues to be a necessity for a unifying survey of the matter.

Download PDF by Sambhu N Datta: Theoretical and Computational Aspects of Magnetic Organic

Natural fabrics with impressive magnetic houses promise quite a lot of mild, versatile, and cheap choices to accepted metal-based magnets. person natural molecules with excessive magnetic moments would be the starting place for layout and fabrication of those fabrics. This booklet offers a scientific realizing of the constitution and homes of natural magnetic molecules.

Extra info for The Chemistry of Organolithium Compounds

Example text

3*8°. Small a m o u n t s o f other products also formed. Five products from dimetallation also obtained. 96% R,R + 4 % R,S. Product had ca. 6 7 % optical p u r i t y . Other products also formed. Prolonged reaction leads to (2-butyl-2-pyridyl) ferrocene as m a i n product. Plus trace monosubstituted. Mixture o f deuterated products obtained o n hydrolysis with D 0 . T h e l,r-disubstituted product predominated even in the early stages of the reaction. Total yield ca. 7 8 % . W i t h an excess o f the reagent, polylithiation o c c u r s .

Ring-metallation is observed in several instances where the organolithium compound also reacts with the substituent. In some cases an excess of the reagent leads to normal or/Atf-metallation; examples are aniline, phenol, and iV-monosubstituted benzamides (see Table 3 . 5 . ) . With thioanisole metallation occurs mainly in the ring, b u t the metal then migrates to the side c h a i n . On the other hand, the a-metallation of toluene apparently takes place directly, rather than by migration from the r i n g / (384b) (145) (145) (176) (50) (414) 5 0 , 6 8 ) Preparation by Metallation 41 F o r the reaction between organolithium compounds a n d halogenobenzenes, alkylation (see Chapter 10) a n d metal-halogen exchange (see Chapter 4) are alternative reactions to metallation.

275. ( 2 7 5 2 7 5 a ) CHCI3 T H ^ ^ C C l L i - S a . ( C C l ) H g 3 3 2 > 90% t Hexamethylphosphorotriamide, (Me N) PO. 2 3 (refs. CCl H B TH 2 U F °1;' . 228) 70% /C0 H AA Ar C=CHCl 2 T H F ,_ B u 4 2 tori^Ar2C^c( n L 5 <§S£ A r C = c ( (refs. 286-7) 2 u p to 9 7 % CF =CFH 2 _ E t i 0 jo 1 0 ) -^gf^ CF -CFLi 2 CF —CF. C(CF ) . OH 63% 2 3 2 (ref. 101) While such reactions have considerable scope, complications may arise from competing metal-halogen exchange (see Chapter 4). F o r example, the reaction of bromochloromethane with n-butyl-lithium in T r a p p mixture " at — 110° gives a mixture of bromochloromethyl-lithium (via metallation) and chloromethyl-lithium (via metal-halogen exchange).

Download PDF sample

The Chemistry of Organolithium Compounds by B. J. Wakefield (Auth.)


by Robert
4.1

Rated 4.70 of 5 – based on 16 votes